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KMID : 0367419780190120030
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Journal of Korean Pediatric Society
1978 Volume.19 No. 12 p.30 ~ p.37
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Clinical Observation on Cerebrospinal fluid Lactic Dehydrogenase Activity.
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이승주/Lee, Seung Joo
고형기/오의숙/안돈희/손근찬/Ko, Hyung Ki/Oh, ESook/Ahn, Don Hee/Sohn, Keun Chan
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Abstract
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Cerebrospinal fluid lactic dehydrogenase activities with other usual laboratory tests were determined in 131 patients including 48 cases of control group with non-CNS disease and 83 cases of various CNS diseases. Mean value of LDH activity in control group (excluding newborn infants) was 31.7 unit and in 8 control newborn infants was S4 unit.
High levels of CSF LDH activity were found in infectious CNS disorders such as pyogenic meningitis, tuberculous meningitis and non infectious CNS disorders including progressive hydrocephalus, cerebrovascular accident, brain or spinal tumor and metastatic carcinoma. Cerebrospinal fluid LDH activities in aseptic meningitis, Guillain-Barre syndrome, poliomyelitis, epilepsy, chorea and uremia were within normal range.
No correlation was found between the levels of CSF LDH activity and the specific etiologic agents or the CIF cell counts and chemistry. Because CSF LDH activity marked the highest level at the extreme of the disease and returned to normal range with recovery of the disease, it is useful as a guidance of antibiotic therapy and an assistant method of prediction of the prognosis.
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